1. charles grashow

    For oral Noopept it’s recommended 1.5 to 3 months with a one month break. How long would you suggest a cycle/break of nasal noopept be?

    1. Ryan Michael Ballow

      It’s a fair question, and I don’t think I can answer it accurately. That’s one of the difficult things with evolutions/deviations from the original method of administration. Oral Noopept’s recommendations for cycling come solely with the idea in mind that the compound gets ingested, passes through the liver, and then starts effecting the brain. Bypassing the liver and going this direct should definitely change the cycling strategy. — That said, I would probably not take Noopept this way for 1.5 months. I’d more (in the interest of safety, based on the fact that there are no studies of safety w/ nasal administration) be inclined to cycle off for a week or two, every 2-3 weeks.

      1. charles grashow

        I found this study – your thoughts

        Comparative Studies of Noopept and Piracetam in the Treatment of Patients with Mild Cognitive Disorders in Organic Brain Diseases of Vascular and Traumatic Origin

        The duration of patients’ involvement in the study included the pre-treatment screening period (seven days) and the treatment period (56 days).

        Noopept was used at a daily dose of 20 mg (as two doses) and piracetam at a daily dose of 1200 mg (as three doses).

        There were no significant differences in the extents of the nootropic effects of Noopept and piracetam. It should only be noted that unlike the balanced profile of the therapeutic activity of Noopept, the action of piracetam included a predominance of psychostimulatory effects, which are undesirable in the treatment of patients with mild cognitive disorders. Noopept had an advantage over piracetam in terms of therapeutic efficacy and safety

        1. Ryan Michael Ballow

          Quite interesting. It seems that a lot of the subjects’ symptoms were alleviated by taking Noopept, and for those symptoms that only started to show signs of improvement toward the end, I suspect they would have been further helped if treatment continued. It also shows that while Piracetam and Noopept are similar in terms of mechanisms of action and effects, Noopept has a better safety profile. I thought it was interesting that some of the Piracetam subjects actually experienced increases in their anxiety symptoms. I am under the impression that, as this study illustrates, Noopept is superior to Piracetam in a variety of ways.

        1. Ryan Michael Ballow

          In terms of safety, I can’t really say. I know there is a large contingent of people that take both Noopept powder sublingually, and fuss with this liquid version of it, but again, I have yet to see any good papers on sublingual noopept. My thoughts on safety are: it’s probably safe to engage in this method of administration a few times a month. It may be safe to engage in sublingual administration everyday, but I just can’t say. My personal strategy would simply be to take it orally. Though it might be less efficient and potent, it offers a peace of mind of safety that I’d take any day over an uncertain experimentation with a different method of admin.

          Risk is inherent in nootropics usage in general I think. Some nootropics deplete neurotransmitter quantity, B vitamins, and possibly other, so there’s risk everywhere. I’m in the camp of trying to mitigate as much risk as possible.

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